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Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity

The major adverse effects of topical retinoids and topical vitamin C are local skin irritation, including erythema, peeling, dryness, burning and itching, which depend on the concentration and formulation of the product (129,130)